IV Question on Nitroprusside 50mg in 250ml of D5W

Hypertension Crisis -- Nitroprusside Administered

Hypertension Crisis -- Nitroprusside Administered

Medication:


Nitroprusside 50mg in 250mL D5W

Dose: 5mcg/kg/min

Patient weight: 143lb


A: How many milliliters per hour?

B: How many milligrams per hour?

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Answer: Millileters Per Hour and Milligrams Per Hour
by: David

First, look at the information we have.

Dose: 5mcg/kg/min

and

Patient weight: 143 lb

We have to convert pounds to kilograms. We do this by multiplying 2.2 (there are 2.2 kilograms in each pound) by 143 lb, which equals 314.6 kilograms.

So now we figure the dose. We multiply 314.6 by 5mcg and we get 1,573 mcg/min.

Now we need to convert micrograms to milligrams. There are 1000 micrograms in 1 milligram. So 1,573 mcg/min = 1.573 mg/min

So, going back to our questions: (We will answer the second question first.)

How many milligrams per hour?

To get milligrams per hour, we take our last answer, 1.573 mg/min and multiply it by 60 (60 min / 1 hour), which equals 94.38 mg/hr.

So back to the first question:

How many milliliters per hour?

Using assumptions from the documentation/package insert on Nipride, there are 200 micrograms/ml

We have mg/hr (94.38 mg/hr from last question.)

Also, we have 1573 mcg/min from the last question.

Now we find milliliters per minute:

Divide 1573 mcg/min by 200 mcg/ml = 7.865 milliliters per minute

Then, to get the answer, we multiply 7.865 milliliters/minute by 60 (sixty minutes in 1 hour) and we get 471.9 milliliters per hour

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